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Deep Learning-Based Molecular Subtyping Identifies Three Biologically Distinct Ovarian Cancer Subtypes with Potential Therapeutic Implications

2026-05-14

Abstract excerpt

<title>Abstract</title> <p>Ovarian cancer exhibits pronounced molecular heterogeneity that complicates therapeutic stratification and patient management. Here we present a comprehensive computational framework integrating variational autoencoders (VAE), probabilistic Gaussian Mixture Model (GMM) clustering, and rigorous consensus stability assessment to deconvolute transcriptomic heterogeneity in 421 high-grade s...

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Literature Corpus work
1c547c2e-6138-5c4e-ab46-94d60bc5a5c2
DOI
10.21203/rs.3.rs-9693642/v1
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