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Article

Distinct transcriptional programs stratify ovarian cancer cell lines into the five major histological subtypes.

Genome medicine - 1 Sept 2021

Barnes Bethany M, Nelson Louisa, Tighe Anthony, Burghel George J, Lin I-Hsuan, Desai Sudha, McGrail Joanne C, Morgan Robert D, Taylor Stephen S

Abstract excerpt

BACKGROUND: Epithelial ovarian cancer (OC) is a heterogenous disease consisting of five major histologically distinct subtypes: high-grade serous (HGSOC), low-grade serous (LGSOC), endometrioid (ENOC), clear cell (CCOC) and mucinous (MOC). Although HGSOC is the most prevalent subtype, representing 70-80% of cases, a 2013 landmark study by Domcke et al. found that the most frequently used OC cell lines are not...

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Identifiers

PMID: 34470661
DOI: 10.1186/s13073-021-00952-5
PMCID: PMC8408985

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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