Article

A cross-disorder analysis of CNVs finds novel loci and dose-dependent relationships of genes to psychiatric traits

2025-07-15

Abstract excerpt

Rare copy number variants (CNVs) are a key component of the genetic basis of psychiatric conditions, but have not been well characterized for most. We conducted a genome-wide CNV analysis across six diagnostic categories (N = 574,965): autism (ASD), ADHD, bipolar disorder (BD), major depressive disorder (MDD), PTSD, and schizophrenia (SCZ). We identified 35 genome-wide significant associations at 18 loci, includin...

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Literature Corpus work: 1c53fd02-04c6-5f08-b430-834a0ea86ce7
DOI: 10.1101/2025.07.11.25331310

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