Back to search

Article

The Functional Interaction Between PRDM16 and the SREBP Pathway Controls Lipid Metabolism

2025-09-02

Abstract excerpt

Dysregulated lipid metabolism is associated with cardiovascular disease, obesity and type 2 diabetes. In the current report we explore the functional interactions between two im-portant regulators of lipid metabolism, sterol regulatory element-binding protein 1 and 2 (SREBP1/2) and PRDI-BF1 and RIZ homology domain containing 16 (PRDM16). The SREBP family of transcription factors regulate cholesterol and fatty acid...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
1c06f188-7a98-58ab-8c36-68a78df0ab81
DOI
10.20944/preprints202509.0096.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The Functional Interaction Between PRDM16 and the SREBP Pathway Controls Lipid MetabolismDOI 10.20944/preprints202509.0096.v1
The Multifaceted Roles of PRDM16: Adipose Biology and Beyond.Semantic proximity
Functions of Prdm16 in thermogenic fat cellsSemantic proximity
Transcriptional control of brown fat determination by PRDM16.Semantic proximity
Androgen Receptor is a Negative Regulator of PRDM16 in Beige AdipocyteSemantic proximity
Role of PRDM16 in the activation of brown fat programming. Relevance to the development of obesity.Semantic proximity
Molecular determinants of brown adipocyte formation and function.Semantic proximity
Promoting brown and beige adipocyte biogenesis through the PRDM16 pathwaySemantic proximity
SETD6-mediated methylation of PPARγ establishes a transcriptional feedback circuit promoting lipid accumulation in liver-derived cellsSemantic proximity
Post-translational control of beige fat biogenesis by PRDM16 stabilizationSemantic proximity
Prdm16 mutation determines sex-specific cardiac metabolism and identifies two novel cardiac metabolic regulators.Semantic proximity
PRDM16 represses the type I interferon response in adipocytes to promote mitochondrial and thermogenic programingSemantic proximity
Association of single nucleotide polymorphism Rs2236518 in PRDM16 gene with BMI in Chinese males.Semantic proximity
Select a neighboring publication to make it the new centre.