Article
Transcriptional control of brown fat determination by PRDM16.
Cell metabolism - 1 Jul 2007
Seale Patrick, Kajimura Shingo, Yang Wenli, Chin Sherry, Rohas Lindsay M, Uldry Marc, Tavernier Geneviève, Langin Dominique, Spiegelman Bruce M
Abstract excerpt
Brown fat cells are specialized to dissipate energy and can counteract obesity; however, the transcriptional basis of their determination is largely unknown. We show here that the zinc-finger protein PRDM16 is highly enriched in brown fat cells compared to white fat cells. When expressed in white...
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