Article

Profiling target engagement and cellular uptake of cRGD-decorated clinical-stage core-crosslinked polymeric micelles

2022-03-30

Abstract excerpt

Polymeric micelles are increasingly explored for tumor-targeted drug delivery. CriPec® technology enables the generation of core-crosslinked polymeric micelles (CCPM) based on thermosensitive (mPEG-b-pHPMAmLac n ) block copolymers, with high drug loading capacity, tailorable size, and controlled drug release kinetics. In this study, we decorated clinical-stage CCPM with the α v β 3 integrin-targeted cyclic arginin...

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Literature Corpus work: 1bfcde50-8854-5b33-abba-417919e5cc68
DOI: 10.21203/rs.3.rs-1372856/v1

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