Article

CCNB1IP1 stabilizes MYCN through suppression of Fbxw7-mediated degradation and facilitates the growth of MYCN-amplified neuroblastoma

2022-07-28

Abstract excerpt

MYCN amplification is the most common genetic alteration and generally represents a negative prognosis for neuroblastoma (NB) patients. However, given the challenge of directly targeting MYCN, indirect strategies to modulate MYCN by interfering with its cofactors is attractive in NB treatment. Here, we showed that the cyclin B1 interacting protein 1 (CCNB1IP1) was highly expressed in MYCN-amplified (MYCN-AM) NB ce...

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Literature Corpus work: 1bb3bd1b-1c8a-5427-a289-b523202758fd
DOI: 10.21203/rs.3.rs-1876730/v1

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