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The deubiquitinase USP28 maintains the expression of the transcription factor MYCN and is essential in neuroblastoma cells

23 May 2023

Abstract excerpt

Neuroblastoma (NB) is one of the most common extracranial solid tumors in children. MYCN gene amplification is highly associated with poor prognosis in high-risk NB patients. In non-MYCN-amplified high-risk NB patients, the expression of c-MYC (MYCC) and its target genes is highly elevated. USP28 as a deubiquitinase is known to regulate the stability of MYCC. We show here USP28 also regulates the stability of...

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PMID: 37230388
DOI: 10.1016/j.jbc.2023.104856

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