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Post-GWAS machine learning prioritizes key genes regulating blood pressure

2023-04-03

Abstract excerpt

<title>Abstract</title> <p>Over one thousand blood pressure (BP) loci have been identified by genetic association studies. However, determination of causal genes remains a bottleneck for further translational discovery. Here we triage genes identified by a BP genome-wide association study (GWAS) using optimized machine learning (ML) methodologies. We investigated regression models with nested cross-validation, be...

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Literature Corpus work: 1bb07787-9379-568f-8bd9-ef1e3af9b466
DOI: 10.21203/rs.3.rs-2402775/v1

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