Article

Multispecific Antibody Development Platform Based on Human Heavy Chain Antibodies

2019-01-07

Abstract excerpt

Heavy chain-only antibodies (HCAbs) do not associate with light chains and their VH regions are functional as single domains, forming the smallest active antibody fragment. These VH regions are ideal building blocks for a variety of antibody-based biologics because they tolerate fusion to other molecules and may also be attached in series to construct multispecific antibodies without the need for protein engineeri...

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Identifiers and source

Literature Corpus work: 1b68bbf5-f35a-5017-b2da-68086a158634
DOI: 10.3389/fimmu.2018.03037

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