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NLRP3-mediated autophagy dysfunction links gut microbiota dysbiosis to tau pathology in chronic sleep deprivation

1 Jan 2024

Abstract excerpt

Growing evidence has shown that sleep deprivation (SD) could result in Alzheimer’s disease (AD)-related pathological changes and cognitive decline. However, potential mechanisms remain obscure. Here, we demonstrated the existence of the microbiota-gut-brain axis in cognitive deficits resulting from chronic SD and revealed a potential pathway by which gut microbiota affected cognitive functioning in chronic SD. We...

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PMID: 39004863
DOI: 10.24272/j.issn.2095-8137.2024.085

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