BRD4 Inhibition Suppresses Senescence and Apoptosis of Nucleus Pulposus Cells by Inducing Autophagy during Intervertebral Disc Degeneration: An In Vitro and In Vivo Study

Abstract excerpt

Intervertebral disc degeneration (IDD) is the most common chronic skeletal muscle degeneration disease. Although the underlying mechanisms remain unclear, nucleus pulposus (NP) autophagy, senescence, and apoptosis are known to play a critical role in this process. Previous studies suggest that bromodomain‐containing protein 4 (BRD4) promotes senescent and apoptotic effects in several age‐related degenerative...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Spine and Intervertebral Disc Pathology