Article

Exceptional diversity and selection pressure on SARS-CoV and SARS-CoV-2 host receptor in bats compared to other mammals

2020-04-20

Abstract excerpt

Pandemics originating from pathogen transmission between animals and humans highlight the broader need to understand how natural hosts have evolved in response to emerging human pathogens and which groups may be susceptible to infection. Here, we investigate angiotensin-converting enzyme 2 (ACE2), the host protein bound by SARS-CoV and SARS-CoV-2. We find that the ACE2 gene is under strong selection pressure in ba...

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Literature Corpus work: 1a261330-1174-5c99-af6e-5a7f9a99dd1f
DOI: 10.1101/2020.04.20.051656

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