Article

Serine/threonine kinase of human Monkeypox virus: computational modeling and structural analysis

2022-12-05

Abstract excerpt

Kinases catalyze phosphoryl transfer from a nucleoside triphosphate (usually ATP) to an amino acid residue on a protein (for activation purposes). These enzymes are well-appreciated drug targets against different viruses and cancers. However, some poxviruses are human and animal pathogens that lack effective therapeutic agents. In poxvirus, the production of infectious particles in the infected cells depends on F1...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 19f3e9cd-ca27-52e8-a23b-fbf375bfb152
DOI: 10.21203/rs.3.rs-2315316/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Serine/threonine kinase of human Monkeypox virus: computational modeling and structural analysisDOI 10.21203/rs.3.rs-2315316/v1Read

The Hunt for antipox compounds against Monkeypox Virus Thymidylate Kinase and scaffolding protein leveraging Pharmacophore modeling, molecular docking, ADMET Studies, and molecular dynamics simulation studiesSemantic proximity Read

Multi-omics characterization of the monkeypox virus infectionSemantic proximity Read

Crystal structure of poxvirus thymidylate kinase: An unexpected dimerization has implications for antiviral therapySemantic proximity Read

Comparative genomics and integrated system biology approach unveiled undirected phylogeny patterns, mutational hot spots, functional patterns and molecule repurposing for monkey pox virusSemantic proximity Read

Deciphering the complete human-monkeypox virus interactome: Identifying immune responses and potential drug targetsSemantic proximity Read

Immunoinformatic and molecular docking approaches: siRNA prediction to silence cell surface binding protein of monkeypox virusSemantic proximity Read

Comparative genomics and integrated system biology approach unveiled undirected phylogeny patterns, mutational hotspots, functional patterns, and molecule repurposing for monkeypox virus.Semantic proximity Read

Novel Multi Epitope-based Vaccine against Monkeypox Virus: Vaccinomic approachSemantic proximity Read

Systematic genetic characterization of the human PKR kinase domain highlights its functional malleability to escape a poxvirus substrate mimic.Semantic proximity Read

Systematic genetic characterization of the human PKR kinase domain highlights its functional malleability to escape a poxvirus substrate mimicSemantic proximity Read

Potential Inhibitors of Lumpy Skin Disease’s Viral Protein (DNA Polymerase): A Combination of Bioinformatics ApproachesSemantic proximity Read

Structure of the Monkeypox profilin-like protein A42R reveals potential function differences from cellular profilinsSemantic proximity Read