Article

Identification of Candidate Diagnostic gene CDC25C for Trametinib-induced Cardiotoxicity by Integrating Bioinformatics and Machine Learning

2024-05-08

Abstract excerpt

<h4>ABSTRACT</h4> Trametinib is a MEK inhibitor that has been shown to have considerable efficacy in retarding melanoma progression. However, the exact mechanism of cardiotoxicity induced by trametinib remains unclear. Our study was designed to investigate the underlying mechanisms by which trametinib-induced cardiotoxicity (TIC) might exist, offering novel perspectives and guidance for potential prediction, diag...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 19bd901d-edda-5052-b346-9f190765b763
DOI: 10.1101/2024.05.06.592660

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of Candidate Diagnostic gene CDC25C for Trametinib-induced Cardiotoxicity by Integrating Bioinformatics and Machine LearningDOI 10.1101/2024.05.06.592660Read

KICDB: A Causality-Oriented Multi-Omics Database for Kinase Inhibitor-Induced CardiotoxicitySemantic proximity Read

Analysis and validation of critical signatures and immune cell infiltration characteristics in doxorubicin-induced cardiotoxicity by integrating bioinformatics and machine learningSemantic proximity Read

Identifying common pathways for doxorubicin and carfilzomib-induced cardiotoxicities: transcriptomic and epigenetic profilingSemantic proximity Read

Selected Ideal Natural Ligand Against TNBC by Inhibiting CDC20, Using Bioinformatics and Molecular BiologySemantic proximity Read

Cytoskeletal gene alterations linked to sorafenib resistance in hepatocellular carcinomaSemantic proximity Read

Investigation of the prognostic biomarkers for thymomaSemantic proximity Read

Upregulation of Biomarker Limd1 Was Correlated with Immune Infiltration in Doxorubicin-Related CardiotoxicitySemantic proximity Read

Identification ACTA2 and KDR as Key Proteins for Prognosis of PD-1/PD-L1 Blockade Therapy in MelanomaSemantic proximity Read

Kinome profiling allows examination and prediction of kinase inhibitor cardiotoxicitySemantic proximity Read

RNA-seq and integrated network analysis reveals the hub genes and key pathway of paclitaxel inhibition on Adriamycin resistant diffuse large B cell lymphoma cellsSemantic proximity Read

predicTox: An integrated database of clinical risk frequencies and human gene expression signatures for cardiotoxic drugsSemantic proximity Read