Massively scalable genetic analysis of antibody repertoires

Abstract excerpt

With technical breakthroughs in the throughput and read-length of next-generation sequencing platforms, antibody repertoire sequencing is becoming an increasingly important tool for detailed characterization of the immune response. There is a need for open, scalable software for the genetic analysis of repertoire-scale antibody sequence data. To address this gap, we have developed the ab[x] package of software too...

Topics

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• Computational Biology
• Genetic Variation
• High-Throughput Nucleotide Sequencing
• Immunoglobulin Heavy Chains
• Immunoglobulin Light Chains
• Monoclonal and Polyclonal Antibodies Research
• T-cell and B-cell Immunology
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

19a654fd-1cfd-57d2-ae4a-e7a829551523

DOI

10.1101/447813