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Article

PPAR-γ Agonists and Their Role in Primary Cicatricial Alopecia

1 Jan 2017

Abstract excerpt

Peroxisome proliferator-activated receptor γ (PPAR-γ) is a ligand-activated nuclear receptor that regulates the transcription of various genes. PPAR-γ plays roles in lipid homeostasis, sebocyte maturation, and peroxisome biogenesis and has shown anti-inflammatory effects. PPAR-γ is highly expressed in human sebaceous glands. Disruption of PPAR-γ is believed to be one of the mechanisms of primary cicatricial...

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PMID: 29333153
DOI: 10.1155/2017/2501248

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