Article

Antidepressant switching as a proxy phenotype for drug non-response: investigating clinical, demographic and genetic characteristics

2024-11-10

Abstract excerpt

<h4>Background</h4> Selective serotonin reuptake inhibitors (SSRIs) are a first-line pharmacological therapy in major depressive disorder (MDD), but treatment response rates are low. Clinical trials lack the power to study the genetic contribution to SSRI response. Real-world evidence from electronic health records provides larger sample sizes, but novel response definitions are needed to accurately define SSRI no...

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Literature Corpus work: 192bd4d6-59c5-5470-bb1d-376c13dc3611
DOI: 10.1101/2024.11.09.24316987

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