Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Antidepressant Switching as a Proxy Phenotype for Drug Nonresponse: Investigating Clinical, Demographic, and Genetic Characteristics

10 Apr 2025

Abstract excerpt

Selective serotonin reuptake inhibitors (SSRIs) are a first-line pharmacological therapy in major depressive disorder (MDD), but treatment response rates are low. Clinical trials lack the power to study the genetic contribution to SSRI response. Real-world evidence from electronic health records provides larger sample sizes, but novel response definitions are needed to accurately define SSRI nonresponders. In the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Associations and Epidemiology
Share to Treatment of Major Depression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40510220
DOI: 10.1016/j.bpsgos.2025.100502

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antidepressant Switching as a Proxy Phenotype for Drug Nonresponse: Investigating Clinical, Demographic, and Genetic CharacteristicsPMID 40510220Read ↗

Antidepressant switching as a proxy phenotype for drug non-response: investigating clinical, demographic and genetic characteristicsSemantic proximity Read ↗

Understanding antidepressant change patterns in the UK BiobankSemantic proximity Read ↗

Cohort Profile: Investigating Antidepressant Response within Generation ScotlandSemantic proximity Read ↗

Cohort Profile: Investigating Antidepressant Response within Generation ScotlandSemantic proximity Read ↗

Sociodemographic, clinical, and genetic factors associated with self-reported antidepressant response outcomes in the UK BiobankSemantic proximity Read ↗

Sociodemographic, clinical, and genetic factors associated with self-reported antidepressant response outcomes in the UK Biobank.Semantic proximity Read ↗

Phenotype-by-phenome-wide association study of treatment resistant depressionSemantic proximity Read ↗

Decoding Treatment Choice: Genetic and Phenotypic Analyses of Long-term Antidepressant AcceptabilitySemantic proximity Read ↗

Understanding response to treatment in depression: Insights from the Pakistani DIVERGE studySemantic proximity Read ↗

Genome-wide meta-analyses of non-response to antidepressants provide insights into underlying molecular genetics and suggest potential pharmacotherapies.Semantic proximity Read ↗

Treatment Resistant Depression in electronic health records: Definitions MatterSemantic proximity Read ↗

The Effects of CYP2C19 Genotype on Proxies of SSRI Antidepressant Response in the UK BiobankSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.