Article

Treatment Resistant Depression in electronic health records: Definitions Matter

2025-12-15

Abstract excerpt

<h4>Background</h4> Many people with depression do not respond well to the first antidepressant prescribed. Treatment Resistant Depression (TRD) refers to depression which does not respond to multiple subsequent antidepressant treatments. Identifying TRD in routinely-collected health records is challenging due to limited response-related data. Previous studies have used definitions based on the number of antidepr...

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Literature Corpus work: b5ba2be7-ac56-538b-ab59-d0e63e2a206d
DOI: 10.64898/2025.12.15.25342069

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