Article

Quantitative fibrosis features from digitized H&E-stained liver biopsies reveal granular insights into fibrosis and disease progression in metabolic dysfunction-associated steatohepatitis: a retrospective analysis of STELLAR-3 and STELLAR-4

2025-06-22

Abstract excerpt

<h4>Background</h4> Histologic staging of metabolic dysfunction-associated steatohepatitis (MASH) requires semiquantitative assessment of hepatocellular ballooning, steatosis, lobular inflammation, and fibrosis and is fraught with pathologist variability. We hypothesize that quantitative histologic analysis will better reflect the continuous distribution of histologic features, and thus the disease biology. <h4>M...

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Literature Corpus work: 19002e0c-59ea-5822-b76b-b8e9b4f52329
DOI: 10.1101/2025.06.12.25328580

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Quantitative fibrosis features from digitized H&E-stained liver biopsies reveal granular insights into fibrosis and disease progression in metabolic dysfunction-associated steatohepatitis: a retrospective analysis of STELLAR-3 and STELLAR-4DOI 10.1101/2025.06.12.25328580Read

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