Article

A Systems approach identifies MERTK as a therapeutic vulnerability in ZFTA-RELA-driven ependymomas

2025-02-08

Abstract excerpt

Ependymomas (EPN) are rare central nervous system tumors that account for approximately 10% of intracranial tumors in children and 4% in adults. Despite their clinical and molecular heterogeneity, spanning supratentorial, posterior fossa, and spinal subtypes, treatment remains limited to surgery and radiotherapy, with chemotherapy offering minimal benefit. Here, we performed transcriptomic analysis of 370 human ep...

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Identifiers and source

Literature Corpus work: 18eb1657-5daf-599f-b6d7-970f2c372df8
DOI: 10.1101/2025.02.06.636949

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