Identification of a Novel HOOK3-FGFR1 Fusion Gene Involved in Activation of The NF-kappaB Pathway

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>Rearrangements involving the fibroblast growth factor receptor 1 (FGFR1) gene result in 8p11 myeloproliferative syndrome (EMS), which is a rare and aggressive hematological malignancy that is often initially diagnosed as myelodysplastic syndrome (MDS). Clinical outcomes are typically poor due to relative resistance to tyrosine kinase inhibitors (TKIs) and rapid tr...

Topics

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• Disease Progression
• Eosinophilic Disorders and Syndromes
• Gene Fusion
• Genomics
• High-Throughput Nucleotide Sequencing
• Molecular Targeted Therapy
• Neoplasms
• Receptors, Fibroblast Growth Factor

Identifiers and source

Literature Corpus work

18b0dc30-9a77-597f-ba26-9ec448c95b99

DOI

10.21203/rs.3.rs-1052427/v1