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Phenotypic Screening Identifies Flunarizine as an Inhibitor of Radiotherapy-Induced Astrocyte Reactivity with Therapeutic Potential in Glioblastoma

2025-07-17

Abstract excerpt

Radiotherapy is part of the standard-of-care for glioblastoma, yet tumors invariably recur as incurable lesions post-treatment. Recent studies suggest that radiation-induced astrocyte reactivity fosters a tumor-supportive environment, however effective strategies targeting reactive astrocyte phenotypes are lacking. Using a novel image-based assay, we screened over 1,700 small molecule compounds, identifying 29 tha...

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Identifiers and source

Literature Corpus work
1886e1fe-b6d7-569a-8c1f-fddb0d9240f7
DOI
10.1101/2025.07.12.664538
Open publication

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Phenotypic Screening Identifies Flunarizine as an Inhibitor of Radiotherapy-Induced Astrocyte Reactivity with Therapeutic Potential in GlioblastomaDOI 10.1101/2025.07.12.664538
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