Article

Long-Read Transcriptome Sequencing and Functional Validation Reveals Novel and Oncogenic Gene Fusions in Fusion Panel-Negative Gliomas

2026-03-17

Abstract excerpt

<h4>ABSTRACT</h4> Gliomas comprise a heterogeneous group of central nervous system tumors in which gene fusions (GFs) are significant oncogenic drivers and emerging diagnostic and therapeutic biomarkers. In cancer diagnosis, GF detection largely relies on targeted short-read sequencing fusion panels, such as the Children’s Hospital of Philadelphia (CHOP) Fusion Panel (FUSIP). While these panels are effective for...

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Literature Corpus work: 18601108-08ee-5786-b1d8-1fec8d09b83f
DOI: 10.64898/2026.03.13.711117

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