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Article

YTHDF1 Promotes Cyclin B1 Translation through m6A Modulation and Contributes to the Poor Prognosis of Lung Adenocarcinoma with KRAS/TP53 Co-Mutation.

Cells - 2 Jul 2021

Lou Xiaoying, Ning Jinfeng, Liu Wei, Li Kexin, Qian Benheng, Xu Danfei, Wu Yue, Zhang Donghong, Cui Wei

Abstract excerpt

KRAS and TP53 mutations are the two most common driver mutations in patients with lung adenocarcinoma (LUAD), and they appear to reduce latency and increase metastatic proclivity when a KRAS and TP53 co-mutation (KRAS/TP53-mut) occurs. However, the molecular mechanism involved is unclear. N6-methyladenosine (m6A), the most abundant RNA modification in mammal mRNAs, plays a critical role in tumorigenesis. Here, we...

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PMID: 34359836
DOI: 10.3390/cells10071669
PMCID: PMC8305181

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YTHDF1 Promotes Cyclin B1 Translation through m6A Modulation and Contributes to the Poor Prognosis of Lung Adenocarcinoma with KRAS/TP53 Co-Mutation.PMID 34359836Read ↗

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