Brain-wide sensory aberrations in a Parkinson’s Disease mouse model revealed by functional MRI

Abstract excerpt

Parkinson’s disease (PD) is associated with irreparable damage to dopaminergic neurons in brain areas involved in movement. Frequently, a very early symptom of PD involves an impaired sense of smell, while other studies suggest a broader impairment of other sensory modalities. Still, the associated brain-wide mechanisms underlying this phenomenon remain unclear. Here, we harness in vivo functional Magnetic Resona...

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• Action Potentials
• Evoked Potentials
• Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
• Mice, Inbred C57BL
• Mice, Knockout
• Odorants
• Olfactory Bulb
• Sensation

Identifiers and source

Literature Corpus work

17b0a1c4-3964-54d4-a163-79c3bfcd3738

DOI

10.1101/2022.04.06.487227