Article
Mutant G2019S-LRRK2 Induces Abnormalities in Arteriolar Cerebral Blood Volume in Mouse Brains: An MRI Study.
Neuro-degenerative diseases - 1 Jan 2020
Ning Bo, Guo Gongbo, Gu Chunming, Xu Jiadi, Bibic Adnan, He Xiaofei, Liu Hongshuai, Chen Lin, Wei Zhiliang, Duan Wenzhen, Liu Peiying, Lu Hanzhang, van Zijl Peter C M, Ross Christopher A, Smith Wanli, Hua Jun
Abstract excerpt
BACKGROUND: Parkinson's disease (PD) is the second most common neurodegenerative disease and the most common movement disorder characterized by motor impairments resulting from midbrain dopamine neuron loss. Abnormalities in small pial arteries and arterioles, which are the primary pathways of local delivery of nutrients and oxygen in brain tissue, have been reported in many neurodegenerative diseases including...
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