Article

Lassa virus NP DEDDh 3′-5′ exoribonuclease activity is required for optimal viral RNA replication and mutation control

2023-04-13

Abstract excerpt

Lassa virus (LASV), a mammarenavirus from Arenaviridae , is the causative agent of Lassa fever (LF) endemic in West Africa. Currently, there are no vaccines or antivirals approved for LF. The RNA-dependent RNA polymerases (RdRp) of RNA viruses are error-prone. As a negative-sense RNA virus, how LASV copes with errors in RNA synthesis and ensures optimal RNA replication are not well elucidated. LASV nucleoprotein...

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Literature Corpus work: 6d0027d6-ea69-541b-bcb7-56cf93620e8c
DOI: 10.1101/2023.04.12.536665

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