Article

Does complexation of plasma membrane cholesterol with phospholipids determine its transbilayer distribution?

2026-07-06

Abstract excerpt

<title>Abstract</title> <p>The transbilayer distribution of cholesterol in the plasma membrane is unresolved in that diverse analyses have yielded contradictory results. We now propose a model based on a new mechanism. It assumes that (a) sterols associate stoichiometrically with phospholipids and (b) these complexes are filled to capacity in the plasma membrane. The sterol in each leaflet is then the product of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 170b2e4c-4ccb-5dfe-a8a5-22d589485068
DOI: 10.21203/rs.3.rs-10220904/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest

Does complexation of plasma membrane cholesterol with phospholipids determine its transbilayer distribution?DOI 10.21203/rs.3.rs-10220904/v1Read

A novel determination of the transbilayer distribution of plasma membrane cholesterolSemantic proximity Read

Cell membranes sustain phospholipid imbalance via cholesterol asymmetrySemantic proximity Read

C24 sphingolipids play a surprising and central role in governing cholesterol and lateral organization of the live cell plasma membraneSemantic proximity Read

A fluid connection: Cholesterol and AβSemantic proximity Read

Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis.Semantic proximity Read

The Role of 1- <i>O</i> -Acylceramide NP in Structural Organization and Permeability of the Stratum Corneum Lipid MatrixSemantic proximity Read

Preferential arrangement of lipids in the long-periodicity phase of a stratum corneum matrix modelSemantic proximity Read

New Insights into Cholesterol Functions: A Friend or an Enemy?Semantic proximity Read