Article

Zinc for GNAO1 encephalopathy: preclinical profiling and a clinical case

2024-01-25

Abstract excerpt

<title>Abstract</title> <p><italic>De novo</italic> mutations in <italic>GNAO1</italic> – the gene encoding the major neuronal G-protein Gαo – cause pediatric encephalopathies largely refractory to available therapies. Zn<sup>2+</sup> emerged to restore GTP hydrolysis and cellular interactions of pathogenic Gαo; dietary Zn<sup>2+</sup> supplementation improves lifespan and motoric function in a <italic>Drosophila...

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Literature Corpus work: 16f7196f-acda-5b9c-90c6-96025eb576b7
DOI: 10.21203/rs.3.rs-3771723/v1

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