Article

Restoration of the GTPase activity of Gαo mutants by Zn2+ in GNAO1 encephalopathy models

2021-09-14

Abstract excerpt

<title>Abstract</title> <p><italic>GNAO1</italic> encephalopathy is a rare pediatric disease characterized by motor dysfunction, developmental delay, and epileptic seizures<sup>1-3</sup>.<italic> De novo</italic> point mutations in the gene encoding Gαo, the major neuronal G protein, lie at the core of this dominant genetic malady<sup>4</sup>. Half of the clinical case mutations fall on codons Gly203, Arg209, or...

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Literature Corpus work: cc5ed627-fe89-50bc-ac92-f27fc1594d51
DOI: 10.21203/rs.3.rs-900405/v1

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