Article
Conditional Modeling of GNAO1 Disorder Dissociates Circuit Specific Contributions to Pathology and Rationalizes Ameliorative Strategies.
Movement disorders : official journal of the Movement Disorder Society - 1 Jun 2026
Brunori Gloria, Zucca Stefano, Lankford Colten K, Wang Yi-Zhi, Franco Marianna, Alekseeva Nina A, Ahmedova Sevinj, Van Han My, Savas Jeffrey N, Martemyanov Kirill A
Abstract excerpt
BACKGROUND: Neurodevelopmental disorders feature various symptoms that frequently include seizures and motor manifestations, but their attribution to disruptions of specific circuits and molecular alterations is notoriously hard to establish, which limits therapeutic interventions. Among these, is the GNAO1 disorder a severe pediatric encephalopathy associated with mutations in a gene encoding G protein subunit...
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