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Integrated rational and evolutionary engineering of genome-reduced <i>Pseudomonas putida</i> strains empowers synthetic formate assimilation

2022-07-10

Abstract excerpt

<h4> A bstract </h4> Formate is a promising, water-soluble C1 feedstock for biotechnology since it can be efficiently produced from CO 2 —but very few industrially-relevant hosts have been engineered towards formatotrophy. Here, the non-pathogenic soil bacterium Pseudomonas putida was adopted as a platform for synthetic formate assimilation. The metabolism of genome-reduced variants of P. putida was rewired...

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Literature Corpus work
16f5056d-d67d-556a-9464-36ba60f16167
DOI
10.1101/2022.07.10.499488
Open publication

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Integrated rational and evolutionary engineering of genome-reduced <i>Pseudomonas putida</i> strains empowers synthetic formate assimilationDOI 10.1101/2022.07.10.499488
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