Article

<i>Helicobacter hepaticus</i> as disease driver in a novel CD40-mediated model of colitis

2020-04-22

Abstract excerpt

<h4>ABSTRACT</h4> Gut microbiota and the immune system are in constant exchange, which shapes both, host immunity and microbial communities. Here, improper immune regulation can cause inflammatory bowel disease (IBD) and colitis. Antibody therapies blocking signaling through the CD40 – CD40L axis showed promising results as these molecules have been described to be deregulated in certain IBD patients. To better u...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 16c2f503-e5f2-5d1c-8123-26d12706caa4
DOI: 10.1101/2020.04.21.053066

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>Helicobacter hepaticus</i> as disease driver in a novel CD40-mediated model of colitisDOI 10.1101/2020.04.21.053066Read

Intestinal inflammation reversibly alters the microbiota to drive susceptibility to <i>Clostridioides difficile</i> colonization in a mouse model of colitisSemantic proximity Read

Inflammation induced T <sub>h</sub> 17 cells synergize with the inflammation-trained microbiota to mediate host-resiliency against intestinal injurySemantic proximity Read

Hsp65-Producing Lactococcus lactis Prevents Inflammatory Intestinal Disease in Mice by IL-10- and TLR2-Dependent PathwaysSemantic proximity Read

Helicobacter-induced inflammatory bowel disease in IL-10- and T cell-deficient mice.Semantic proximity Read

Loss of IL-10 signaling promotes IL-22 dependent host defenses against acute <i>Clostridioides difficile</i> infectionSemantic proximity Read

Intestinal inflammation and altered gut microbiota associated with inflammatory bowel disease renders mice susceptible to <i>Clostridioides difficile</i> colonization and infectionSemantic proximity Read

Strain-specific colitis susceptibility in IL10-deficient mice depends on complex gut microbiota–host interactionsSemantic proximity Read

Enteric infection priming confers IL-17A–dependent protection from chemically-induced ColitisSemantic proximity Read

Inflammation, Immunity, and Vaccines for HelicobacterSemantic proximity Read

AntigenB drives M1/M2 polarization following Echinococcus granulosus infection in inflammatory bowel diseaseSemantic proximity Read

Tolerogenic Dendritic Cells Shape a Transmissible Gut Microbiota that Protects from Metabolic DiseasesSemantic proximity Read

Autoimmune Intestinal Pathology Induced by hsp60-Specific CD8 T CellsSemantic proximity Read