Article

Mechanistically explainable AI model for predicting synergistic cancer therapy combinations

2025-08-12

Abstract excerpt

This study introduces a Large Language Model (LLM)-based framework that combines drug combination data with a knowledge graph to predict synergistic oncology drug combinations with mechanistic insights. Using a retrieval-augmented generation (RAG) approach, over 50,000 in vitro drug pair assay results and 1,631 human clinical trial or preclinical test entries were integrated to enhance predictive accuracy and exp...

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Literature Corpus work: 15542a06-726a-5d36-ba70-f512b60f1e2d
DOI: 10.1101/2025.08.10.669494

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