Article

Breaking the redundancy: TAZ outperforms YAP1 in GIST progression

2025-09-07

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Gastrointestinal stromal tumors (GIST) are mainly caused by gain-of-function mutations in KIT or PDGFRA genes and are the most common neoplasms of the digestive tract. Imatinib (IM), a tyrosine kinase inhibitor (TKI) targeting these oncogenic drivers, has considerably improved patient outcomes, although resistance remains a major challenge. The transcriptional co-activator...

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Literature Corpus work: 0e7cbccb-0194-563f-bf00-8a2642170a5d
DOI: 10.1101/2025.09.02.673653

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