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Article

Drosophila sensory cilia lacking MKS proteins exhibit striking defects in development but only subtle defects in adults.

Journal of cell science - 15 Oct 2016

Pratt Metta B, Titlow Joshua S, Davis Ilan, Barker Amy R, Dawe Helen R, Raff Jordan W, Roque Helio

Abstract excerpt

Cilia are conserved organelles that have important motility, sensory and signalling roles. The transition zone (TZ) at the base of the cilium is crucial for cilia function, and defects in several TZ proteins are associated with human congenital ciliopathies such as nephronophthisis (NPHP) and Meckel-Gruber syndrome (MKS). In several species, MKS and NPHP proteins form separate complexes that cooperate with Cep290...

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Identifiers

PMID: 27577095
DOI: 10.1242/jcs.194621
PMCID: PMC5087661

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Drosophila sensory cilia lacking MKS proteins exhibit striking defects in development but only subtle defects in adults.PMID 27577095Read ↗

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