Article

Assessing Immune Stability in Space: Haematological and T Cell Profiling of Astronauts During the MESSAGE Science Mission in Axiom-3 on the ISS

2025-04-10

Abstract excerpt

Microgravity presents unique challenges to human physiology, particularly the immune system, during spaceflight. T lymphocytes, key components of adaptive immunity, play a vital role in immune regulation, yet the effects of microgravity on T-cell function and gene expression remain incompletely understood. This study, conducted as part of the MESSAGE (Microgravity Associated Genetics) Science Mission in the Axiom-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: afe11562-89d6-5915-83a5-04f334cae346
DOI: 10.1101/2025.04.09.647940

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Assessing Immune Stability in Space: Haematological and T Cell Profiling of Astronauts During the MESSAGE Science Mission in Axiom-3 on the ISSDOI 10.1101/2025.04.09.647940Read

Microgravity-Induced Immune Plasticity and Temporal Modulation of Gene Networks and T Cell Subsets During the MESSAGE Science Mission in Axiom-3 on the ISSSemantic proximity Read

Genome and clonal hematopoiesis stability contrasts with immune, cfDNA, mitochondrial, and telomere length changes during short duration spaceflightSemantic proximity Read

3D microenvironment attenuates simulated microgravity-mediated changes in T cell transcriptomeSemantic proximity Read

Longitudinal transcriptomic and epigenetic analysis in astronauts reveals dynamic immune response to spaceflightSemantic proximity Read

Spaceflight modulates gene expression in the whole blood of astronautsSemantic proximity Read

A Longitudinal Epigenetic Aging and Leukocyte Analysis of Simulated Space Travel: The Mars-500 MissionSemantic proximity Read

Designing a novel monitoring approach for the effects of space travel on astronauts’ healthSemantic proximity Read

Single-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflightSemantic proximity Read

Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflightSemantic proximity Read

Hypothetical LOC Genes as Biomarkers of Spaceflight Adaptation: A Comparative Study from ISS, Suborbital, and Earth-Based ExperimentsSemantic proximity Read

T cell regulation in microgravity – The current knowledge from in vitro experiments conducted in space, parabolic flights and ground-based facilitiesSemantic proximity Read

The NASA Twins Study: A multidimensional analysis of a year-long human spaceflightSemantic proximity Read