Article
Metal-based anticancer drugs: From a past anchored in platinum chemistry to a post-genomic future of diverse chemistry and biology
2007-01-01
Abstract excerpt
Abstract The field of metal-based anticancer drugs was initiated by cisplatin, one of the leading agents in clinical use. Cisplatin acts by binding to DNA and forming 1,2 intrastrand cross-links. Its importance is reflected by the fact that it is estimated that 50-70 % of cancer patients are treated with a platinum drug [7]. For some time, molecular designs in the metallo-drug field remained obdurately anchored in...
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Identifiers and source
- Literature Corpus work
- 2fc05a08-eae1-5c5d-b517-4225cf2cf7ba
- DOI
- 10.1351/pac200779122243