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Article

Protease FRET Reporters Targeting Neutrophil Extracellular Traps

13 Nov 2020

Abstract excerpt

Neutrophil extracellular traps (NETs) consist of DNA released by terminally stimulated neutrophils. They fine-tune inflammation, kill pathogens, activate macrophages, contribute to airway mucus obstruction in cystic fibrosis, and facilitate tumor metastasis after dormancy. Neutrophil proteases such as elastase (NE) and cathepsin G (CG) attach to NETs and contribute to the diverse immune outcome. However, because...

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PMID: 33186023
DOI: 10.1021/jacs.0c08130

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