Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HIV genetic variation is directed and restricted by DNA precursor availability.

Journal of molecular biology - 11 Jul 1997

Vartanian J P, Plikat U, Henry M, Mahieux R, Guillemot L, Meyerhans A, Wain-Hobson S

Abstract excerpt

The effects of deoxynucleoside triphosphate (dNTP) imbalances on the fidelity of human immunodeficiency virus type 1 (HIV-1) replication were investigated. Using detergent permeabilized virions and biased dNTP concentrations different types of hypermutants were readily produced. However, the mutant spectrum was different from naturally occurring hypermutants demonstrating that the host cell may restrict...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Cell Line
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukocytes, Mononuclear

Share to Molecular Sequence Data

Share to Monocytes

Share to Mutagenesis

Source

Identifiers

PMID: 9236117
DOI: 10.1006/jmbi.1997.1104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HIV genetic variation is directed and restricted by DNA precursor availability.PMID 9236117Read ↗

Increased G-->A transition frequencies displayed by primer grip mutants of human immunodeficiency virus type 1 reverse transcriptase.Semantic proximity Read ↗

Human immunodeficiency virus type 1 DNA sequences genetically damaged by hypermutation are often abundant in patient peripheral blood mononuclear cells and may be generated during near-simultaneous infection and activation of CD4(+) T cells.Semantic proximity Read ↗

Haploid Screening for the Identification of Host Factors in Virus Infection.Semantic proximity Read ↗

APOBEC3G induces a hypermutation gradient: purifying selection at multiple steps during HIV-1 replication results in levels of G-to-A mutations that are high in DNA, intermediate in cellular viral RNA, and low in virion RNA.Semantic proximity Read ↗

Endogenous origins of HIV-1 G-to-A hypermutation and restriction in the nonpermissive T cell line CEM2n.Semantic proximity Read ↗

Variable contexts and levels of hypermutation in HIV-1 proviral genomes recovered from primary peripheral blood mononuclear cells.Semantic proximity Read ↗

Sustained G-->A hypermutation during reverse transcription of an entire human immunodeficiency virus type 1 strain Vau group O genome.Semantic proximity Read ↗

Hypermutation of HIV-1 DNA in the absence of the Vif protein.Semantic proximity Read ↗

Primary T-lymphocytes rescue the replication of HIV-1 DIS RNA mutants in part by facilitating reverse transcription.Semantic proximity Read ↗

Uracil DNA glycosylase initiates degradation of HIV-1 cDNA containing misincorporated dUTP and prevents viral integration.Semantic proximity Read ↗

Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools.Semantic proximity Read ↗

APOBEC3G is a single-stranded DNA cytidine deaminase and functions independently of HIV reverse transcriptaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.