Article

Peroxisome protein import deficiency causes heart failure in mouse and human

2025-10-14

Abstract excerpt

Peroxisomes are ubiquitous cellular organelles with potentially vital roles in lipid and reactive oxygen metabolism. The metabolic demands of the heart are substantial; however, the contribution of peroxisomes to cardiac development, health, and their role in heart failure (HF) remain largely unexplored. We developed and examined a mouse and an engineered human myocardium (EHM) model with a deficiency in cardiac p...

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Identifiers and source

Literature Corpus work: 148bb85b-bc98-5d2b-9ef1-58a60294a6bb
DOI: 10.1101/2025.10.13.681307

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