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Article

Longitudinal Blood DNA Methylation Changes During Weight-Loss Intervention and Dementia Progression Risk

2026-06-17

Abstract excerpt

<title>Abstract</title> <p> Background Weight loss improves metabolic health, but the DNA methylation (DNAm) changes induced by the lifestyle intervention and their relevance to dementia outcomes remain unclear. We studied longitudinal blood DNAm changes during an 18-month weight-loss intervention in the CENTRAL clinical trial and evaluated their relevance to dementia progression in an external cohort. Methods...

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Literature Corpus work
145e0782-cb06-50f4-9f25-6fd592a752de
DOI
10.21203/rs.3.rs-10029889/v1
Open publication

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Longitudinal Blood DNA Methylation Changes During Weight-Loss Intervention and Dementia Progression RiskDOI 10.21203/rs.3.rs-10029889/v1
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