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Article

Lifestyle weight-loss intervention may attenuate methylation aging: the CENTRAL MRI randomized controlled trial

4 Mar 2021

Abstract excerpt

BACKGROUND: DNA methylation age (mAge), a methylation biomarker for the aging process, might serve as a more accurate predictor of morbidity and aging status than chronological age. We evaluated the role of multiple factors, including fat deposition, cardiometabolic risk factors and lifestyle weight-loss intervention, on the deviation of mAge from chronological age (mAge deviation) or 18-month change in mAge...

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PMID: 33663610
DOI: 10.1186/s13148-021-01038-0

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