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Weight management intervention identifies association of decreased DNA methylation age with improved functional age measures in older adults with obesity

2 Mar 2021

Abstract excerpt

BACKGROUND: Assessing functional ability is an important component of understanding healthy aging. Objective measures of functional ability include grip strength, gait speed, sit-to-stand time, and 6-min walk distance. Using samples from a weight loss clinical trial in older adults with obesity, we examined the association between changes in physical function and DNA-methylation-based biological age at baseline...

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PMID: 33653394
DOI: 10.1186/s13148-021-01031-7

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