Article
The RASopathies: Biology, genetics and therapeutic options.
Advances in cancer research - 1 Jan 2022
Longo Jody Fromm, Carroll Steven L
Abstract excerpt
The RASopathies are a group of genetic diseases in which the Ras/MAPK signaling pathway is inappropriately activated as a result of mutations in genes encoding proteins within this pathway. As their causative mutations have been identified, this group of diseases has expanded to include neurofibromatosis type 1 (NF1), Legius syndrome, Noonan syndrome, CBL syndrome, Noonan syndrome-like disorder with loose anagen...
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