Article
Germline and sporadic cancers driven by the RAS pathway: parallels and contrasts.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Jul 2020
Dunnett-Kane V, Burkitt-Wright E, Blackhall F H, Malliri A, Evans D G, Lindsay C R
Abstract excerpt
Somatic mutations in RAS and related pathway genes such as NF1 have been strongly implicated in the development of cancer while also being implicated in a diverse group of developmental disorders named the 'RASopathies', including neurofibromatosis type 1 (NF1), Noonan syndrome (NS), Noonan syndrome with multiple lentigines (NSML), Costello syndrome (CS), cardiofaciocutaneous syndrome (CFC), and capillary...
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