Article

Phenotypic Changes of Detrusor PDGFR Alpha Positive Cells in Spinal Cord Injury-Induced Detrusor Overactivity

2021-05-13

Abstract excerpt

Volume accommodation occurs via a novel mechanism involving interstitial cells in detrusor muscles. The interstitial cells in the bladder are PDGFRα + , and they restrain the excitability of smooth muscle at low levels and prevent the development of transient contractions (TCs). A common clinical manifestation of spinal cord injury (SCI)-induced bladder dysfunction is detrusor overactivity (DO). Although a myogeni...

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Literature Corpus work: 14224a16-0385-5a50-ba47-8ab281943ac4
DOI: 10.21203/rs.3.rs-505840/v1

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