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Point mutations in the ygiV promoter region lead to cystobactamid resistance and reduced virulence in E. coli

2024-01-05

Abstract excerpt

<title>Abstract</title> <p>Antimicrobial resistance is one of the major health threats of the modern world. Thus, new structural classes of antimicrobial compounds are needed in order to overcome existing resistance. Cystobactamids as such a new compound class inhibit the well-established target bacterial type II topoisomerases while exhibiting superior antibacterial and resistance-breaking properties. Understand...

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Literature Corpus work
140a7654-12bc-5ebf-975b-47f669d1ecff
DOI
10.21203/rs.3.rs-3751821/v1
Open publication

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Point mutations in the ygiV promoter region lead to cystobactamid resistance and reduced virulence in E. coliDOI 10.21203/rs.3.rs-3751821/v1
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